Referenced in: none

Automatically associated channels: Kv11.1

Title: [Comparative pharmacophore analysis of dual dopamine D2/5-HT(2A) receptor antagonists]

Authors: Yan-shen Guo, Zong-ru Guo

Journal, date & volume: Yao Xue Xue Bao, 2009 Mar , 44, 314-20

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19449530

Abstract
Dual dopamine D2/5-HT2A receptor antagonists have potent activity and are referred to atypical antipsychotics due to their lower propensity to elicit EPS and their moderate efficacy toward negative symptoms. However, an on-going challenge in developing atypical antipsychotics drugs is to maintain the favorable profiles and avoid of cardiovascular risk. In this paper, comparative pharmacophore analysis of dual dopamine D2/5-HT2A receptor antagonists, hERG K+ channel blockers, and alA adrenoceptor antagonists is carried out, and the results could give some insight into multi-target drug design.