Referenced in: none

Automatically associated channels: Kv11.1

Title: Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG.

Authors: Kenneth M Meyers, Nicholas Kim, José L Méndez-Andino, X Eric Hu, Rashid N Mumin, Sean R Klopfenstein, John A Wos, Maria C Mitchell, Jennifer L Paris, David C Ackley, Jerry K Holbert, Scott W Mittelstadt, Ofer Reizes

Journal, date & volume: Bioorg. Med. Chem. Lett., 2007 Feb 1 , 17, 814-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/17107791

Abstract
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.