Referenced in: none

Automatically associated channels: Kv11.1

Title: 1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: Part 2.

Authors: Christopher G Barber, David C Blakemore, Jean-Yves Chiva, Rachel L Eastwood, Donald S Middleton, Kerry A Paradowski

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Mar 1 , 19, 1499-503

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/19185490

Abstract
Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.