Targeting ions-induced autophagy in cancer.

Francesco Cecconi, Marja Jäättelä

Cancer Cell, 2014 Nov 10 , 26, 599-600

Autophagy is an important cellular homeostasis pathway, but its role in cancer remains to be fully elucidated. In this issue of Cancer Cell, Hall and colleagues describe a TRPM3-dependent autophagy pathway that is selectively important for clear cell renal cell carcinoma and can be effectively inhibited.