Channelpedia

Kv7.1 Channel

Published literature references

Introduction

  1. Charpentier F. et al. Delayed rectifier K(+) currents and cardiac repolarization.
    J. Mol. Cell. Cardiol., 2010 Jan , 48 (37-44).

  2. Georgijević Milić L. et al. [Molecular genetics in the hereditary form of long QT syndrome]
    Med. Pregl., 2000 Jan-Feb , 53 (51-4).

  3. Wang Q. et al. Genetics, molecular mechanisms and management of long QT syndrome.
    Ann. Med., 1998 Feb , 30 (58-65).

  4. Kaczmarek L. et al. Properties and regulation of the minK potassium channel protein.
    Physiol. Rev., 1997 Jul , 77 (627-41).

  5. Schwartz P. et al. Molecular biology of the long QT syndrome: impact on management.
    , 1997 Aug , 20 (2052-7).

  6. Kaneko Y. et al. [Long QT syndrome]
    Nippon Rinsho, 1996 Mar , 54 (776-81).

Gene

  1. Rees M. et al. Posthumous diagnosis of long QT syndrome from neonatal screening cards.
    Heart Rhythm, 2010 Apr , 7 (481-6).

  2. Aurlien D. et al. New SCN5A mutation in a SUDEP victim with idiopathic epilepsy.
    , 2009 Mar , 18 (158-60).

  3. Tenenbaum M. et al. Identification of the gene causing long QT syndrome in an Israeli family.
    Isr. Med. Assoc. J., 2008 Nov , 10 (809-11).

  4. Ager E. et al. Evolution of the CDKN1C-KCNQ1 imprinted domain.
    BMC Evol. Biol., 2008 , 8 (163).

  5. Olszak-Waśkiewicz M. et al. Novel KCNQ1 mutations in patients after myocardial infarction.
    , 2008 , 15 (252-60).

  6. Katus H. et al. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome.
    J. Biol. Chem., 2006 Nov 17 , 281 (35397-403).

  7. Redrup L. et al. Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.
    Development, 2006 Nov , 133 (4203-10).

  8. Leren T. et al. [DNA-based diagnostics of long QT syndrome]
    Tidsskr. Nor. Laegeforen., 2005 Oct 20 , 125 (2783-6).

  9. Li W. et al. [Relationship between congenital long QT syndrome and Brugada syndrome gene mutation]
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2005 Jun , 27 (289-94).

  10. Li C. et al. [Heterozygous mutation in KCNQ1 cause Jervell and Lange-Nielsen syndrome]
    Zhonghua Xin Xue Guan Bing Za Zhi, 2005 Jan , 33 (41-4).

  11. Thomas D. et al. Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome.
    Biochim. Biophys. Acta, 2004 Nov 5 , 1690 (185-92).

  12. Li C. et al. [The mutation scanning of KCNQ1 gene for 31 long QT syndrome families]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2004 Jun , 21 (236-9).

  13. Liang L. et al. [A novel KCNQ1 mutation in Chinese with congenital long QT syndrome]
    Zhonghua Er Ke Za Zhi, 2003 Oct , 41 (724-7).

  14. Wang Y. et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation.
    Science, 2003 Jan 10 , 299 (251-4).

  15. Weksberg R. et al. Insulator and silencer sequences in the imprinted region of human chromosome 11p15.5.
    Hum. Mol. Genet., 2003 Aug 1 , 12 (1927-39).

  16. Georgijević Milić L. et al. [Molecular genetics in the hereditary form of long QT syndrome]
    Med. Pregl., 2000 Jan-Feb , 53 (51-4).

  17. Wang Q. et al. Homozygous deletion in KVLQT1 associated with Jervell and Lange-Nielsen syndrome.
    Circulation, 1999 Mar 16 , 99 (1344-7).

  18. Wang Q. et al. Genetics, molecular mechanisms and management of long QT syndrome.
    Ann. Med., 1998 Feb , 30 (58-65).

  19. Schwartz P. et al. Molecular biology of the long QT syndrome: impact on management.
    , 1997 Aug , 20 (2052-7).

  20. Schwartz P. et al. A molecular basis for the therapy of the long QT syndrome.
    Arch Mal Coeur Vaiss, 1996 Sep , 89 (1185-7).

  21. Kaneko Y. et al. [Long QT syndrome]
    Nippon Rinsho, 1996 Mar , 54 (776-81).

Transcript

No data for this section

Ontology

No data for this section

Interaction

  1. Lau C. et al. Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase.
    Biochim. Biophys. Acta, 2010 May , 1798 (995-1001).

  2. Charpentier F. et al. Delayed rectifier K(+) currents and cardiac repolarization.
    J. Mol. Cell. Cardiol., 2010 Jan , 48 (37-44).

  3. Greenwood I. et al. Expression and function of K(v)7 channels in murine myometrium throughout oestrous cycle.
    Pflugers Arch., 2009 Mar , 457 (1111-20).

  4. Schwarz M. et al. The novel C-terminal KCNQ1 mutation M520R alters protein trafficking.
    Biochem. Biophys. Res. Commun., 2007 Jun 22 , 358 (304-10).

  5. Kwon Y. et al. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6.
    Mol. Cell, 2007 Feb 23 , 25 (491-503).

  6. Knollmann B. et al. Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart.
    Biochem. Biophys. Res. Commun., 2007 Aug 17 , 360 (212-8).

  7. Pongs O. et al. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
    Hum. Mol. Genet., 2006 Oct 1 , 15 (2888-902).

  8. Lang F. et al. KCNQ1-dependent transport in renal and gastrointestinal epithelia.
    Proc. Natl. Acad. Sci. U.S.A., 2005 Dec 6 , 102 (17864-9).

  9. Stockand J. et al. Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.
    J. Neurosci., 2003 Jan 1 , 23 (84-95).

  10. Kass R. et al. Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel.
    Proc. Natl. Acad. Sci. U.S.A., 2003 Feb 18 , 100 (2122-7).

  11. Cui J. et al. Cyclic AMP regulates the HERG K(+) channel by dual pathways.
    Curr. Biol., 2000 Jun 1 , 10 (671-4).

  12. Maher E. et al. Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome.
    J. Med. Genet., 2000 Dec , 37 (921-6).

  13. Wilde A. et al. Long-term (subacute) potassium treatment in congenital HERG-related long QT syndrome (LQTS2).
    J. Cardiovasc. Electrophysiol., 1999 Feb , 10 (229-33).

  14. Kaczmarek L. et al. Properties and regulation of the minK potassium channel protein.
    Physiol. Rev., 1997 Jul , 77 (627-41).

Protein

  1. Vanoye C. et al. Functional delivery of a membrane protein into oocyte membranes using bicelles.
    Biochemistry, 2010 Feb 2 , 49 (653-5).

  2. Ikrar T. et al. Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel.
    Biochem. Biophys. Res. Commun., 2009 Jan 16 , 378 (589-94).

  3. George A. et al. KCNE4 domains required for inhibition of KCNQ1.
    J. Physiol. (Lond.), 2009 Jan 15 , 587 (303-14).

  4. Ma A. et al. [Gene mutation analysis of a Chinese family of congenital long Q-T syndrome type three.]
    Zhonghua Er Ke Za Zhi, 2009 Dec , 47 (926-30).

  5. Labro A. et al. Role of the S6 C-terminus in KCNQ1 channel gating.
    J. Physiol. (Lond.), 2007 Dec 1 , 585 (325-37).

  6. Pongs O. et al. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.
    Hum. Mol. Genet., 2006 Oct 1 , 15 (2888-902).

  7. Haverkamp W. et al. [18-year old patient with anti-epileptic therapy and sudden cardiac death]
    Z Kardiol, 2003 Sep , 92 (747-53).

  8. . et al. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome.
    J. Cardiovasc. Electrophysiol., 2003 Nov , 14 (1149-53).

  9. Pongs O. et al. KCNQ1 channels sense small changes in cell volume.
    J. Physiol. (Lond.), 2003 Jun 1 , 549 (419-27).

  10. Maljevic S. et al. C-terminal interaction of KCNQ2 and KCNQ3 K+ channels.
    J. Physiol. (Lond.), 2003 Apr 15 , 548 (353-60).

  11. George A. et al. MinK subdomains that mediate modulation of and association with KvLQT1.
    J. Gen. Physiol., 2000 Sep , 116 (379-90).

Structure

Distribution

  1. Sanguinetti M. et al. Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
    Naunyn Schmiedebergs Arch. Pharmacol., 2004 Dec , 370 (484-91).

  2. Kang J. et al. Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels.
    Eur. J. Pharmacol., 2003 Jan 1 , 458 (25-9).

  3. Schwartz P. et al. Molecular biology of the long QT syndrome: impact on management.
    , 1997 Aug , 20 (2052-7).

Expression

  1. Kupershmidt S. et al. Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles.
    Heart Rhythm, 2010 Jul , 7 (973-80).

  2. Li W. et al. The G314S KCNQ1 mutation exerts a dominant-negative effect on expression of KCNQ1 channels in oocytes.
    Biochem. Biophys. Res. Commun., 2009 May 29 , 383 (206-9).

  3. Li W. et al. Congenital long QT syndrome caused by the F275S KCNQ1 mutation: mechanism of impaired channel function.
    Biochem. Biophys. Res. Commun., 2009 Feb 27 , 380 (127-31).

  4. George A. et al. KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex.
    FEBS J., 2008 Mar , 275 (1336-49).

  5. Klaerke D. et al. The KCNE1 beta-subunit exerts a transient effect on the KCNQ1 K+ channel.
    Biochem. Biophys. Res. Commun., 2007 Nov 9 , 363 (133-9).

  6. Wu L. et al. Induction of high STAT1 expression in transgenic mice with LQTS and heart failure.
    Biochem. Biophys. Res. Commun., 2007 Jun 29 , 358 (449-54).

  7. Olesen S. et al. The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
    Biochem. Biophys. Res. Commun., 2006 Mar 24 , 341 (979-88).

  8. Vos M. et al. Molecular and electrical characterization of the canine cardiac ventricular septum.
    J. Mol. Cell. Cardiol., 2005 Jan , 38 (153-61).

  9. Olesen S. et al. Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.
    Am. J. Physiol. Heart Circ. Physiol., 2004 Apr , 286 (H1300-9).

  10. Bertaso F. et al. Expression of voltage-gated K+ channels in human atrium.
    Basic Res. Cardiol., 2002 Nov , 97 (424-33).

  11. Olesen S. et al. KCNE4 is an inhibitory subunit to the KCNQ1 channel.
    J. Physiol. (Lond.), 2002 Jul 1 , 542 (119-30).

  12. Tsuji K. et al. Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome.
    J. Cardiovasc. Electrophysiol., 1999 Sep , 10 (1262-70).

  13. Wang Z. et al. Functional effects of mutations in KvLQT1 that cause long QT syndrome.
    J. Cardiovasc. Electrophysiol., 1999 Jun , 10 (817-26).

Functional

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Kinetics

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Model

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Credits

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See all the possible references for Kv7.1