Referenced in: none

Automatically associated channels: Kv1.4 , Kv1.5 , Kv3.1 , Kv4.2 , Kv4.3

Title: Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization.

Authors: Hikaru Tanaka, Iyuki Namekata, Shogo Hamaguchi, Taro Kawamura, Hiroyuki Masuda, Yoshio Tanaka, Naoko Iida-Tanaka, Akira Takahara

Journal, date & volume: Biol. Pharm. Bull., 2010 Jan , 33, 138-41

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20045952

Abstract
Effects of NIP-142, a benzopyran compound which terminates experimental atrial arrhythmia, on potassium channel alpha-subunits and mouse atrial repolarization were examined. NIP-142 concentration-dependently blocked the outward current through potassium channel alpha subunits Kv1.5, Kv4.2 and Kv4.3 expressed in Xenopus oocytes. In isolated mouse atrial myocardia, NIP-142 prolonged the action potential duration and effective refractory period, and increased the contractile force. These results suggest that NIP-142 blocks the potassium channels underlying the transient and sustained outward currents, which may contribute to its antiarrhythmic activity.