Kv12
The Kv12, Elk subfamily of K+ channels, was first discovered in Drosophila on the basis of homology to the Drosophila Eag K+ channel [791]. Subsequently, three distinct mammalian Elk K+ channel genes have been identified [809], [810], [790]. Some level of confusion has been generated in the naming of these Elk genes, because the same names were given to distinct genes in two publications. Here we refer to the Elk gene presented by Shi et al. [[790] (#a790) as KCNH8. (From [808])
The Kv12, Elk subfamily forms part of the Eag family, which consists of three closely related subfamilies of genes defined by sequence homology: Eag, Erg (ether-a-go-go related gene), and Elk (ether-a-go-go-like K+ channel). Each of the three subfamilies is defined by the high degree of homology shared among members. A somewhat lower level of homology is shared between subfamilies (40% amino acid identity). All three subfamilies are conserved between Drosophila and mammals, suggesting an early origin in metazoan evolution.
References
Shi W
et al.
Identification of two nervous system-specific members of the erg potassium channel gene family.
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Warmke JW
et al.
A family of potassium channel genes related to eag in Drosophila and mammals.
Proc. Natl. Acad. Sci. U.S.A.,
1994
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Zou A
et al.
Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Am. J. Physiol., Cell Physiol.,
2003
Dec
, 285 (C1356-66).
Engeland B
et al.
Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.
J. Physiol. (Lond.),
1998
Dec
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, 513 ( Pt 3) (647-54).
Miyake A
et al.
New ether-à-go-go K(+) channel family members localized in human telencephalon.
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1999
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, 274 (25018-25).
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