Referenced in: none

Automatically associated channels: Kv1.5

Title: Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.

Authors: Douglas C Beshore, Nigel J Liverton, Charles J McIntyre, Christopher F Claiborne, Brian Libby, J Christopher Culberson, Joseph J Salata, Christopher P Regan, Joseph J Lynch, Laszlo Kiss, Robert H Spencer, Stephanie A Kane, Rebecca B White, Suzie Yeh, George D Hartman, Christopher J Dinsmore

Journal, date & volume: Bioorg. Med. Chem. Lett., 2010 Apr 15 , 20, 2493-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20304642

Abstract
A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure-activity relationship (SAR) studies described herein led to the development of potent, selective and orally active inhibitors of Kv1.5.