Referenced in: none

Automatically associated channels: Kv1.5 , Kv11.1

Title: Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers.

Authors: Andrew Fluxe, Shengde Wu, James B Sheffer, John M Janusz, Michael Murawsky, Gina M Fadayel, Bin Fang, Michelle Hare, Laurent Djandjighian

Journal, date & volume: Bioorg. Med. Chem. Lett., 2006 Nov 15 , 16, 5855-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16942878

Abstract
A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).