Referenced in: none

Automatically associated channels: Kv11.1 , Kv8.2

Title: Novel roles for hERG K(+) channels in cell proliferation and apoptosis.

Authors: J Jehle, P A Schweizer, H A Katus, D Thomas

Journal, date & volume: Cell Death Dis, 2011 , 2, e193

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21850047

Abstract
The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K(+) channels as future drug target in anticancer therapy is highlighted.