Referenced in: none

Automatically associated channels: ClC4

Title: Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice.

Authors: Elena Martin-Garcia, Francesco Mannara, Javier Gutiérrez-Cuesta, Lidia Sabater, Josep Dalmau, Rafael Maldonado, Francesc Graus

Journal, date & volume: J. Neuroimmunol., 2013 Aug 15 , 261, 53-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23726906

Abstract
The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC.